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- He first gained fame as the prepubescent prodigy Doogie Howser, M.D., a role that won him three Young Artist Awards and a Golden Globe nomination.
- Guest spots on Blossom; Roseanne; Quantum Leap; Murder, She Wrote and Will and Grace followed. He has also lent his voice to several animated series, voicing such famous superhero characters as Spider-Man and The Flash.
- For his feature film debut in Clara's Heart, he received his second Golden Globe nod. He has also appeared in Starship Troopers and The Next Best Thing.
- His first stage role was in a school production of The Wizard of Oz ... as Toto. On Broadway, he has starred in the musicals Rent, Cabaret and Assassins and played Toby in a televised concert version of Sweeney Todd.
- He currently co-stars on How I Met Your Mother, in his Emmy nominated role as the womanizing Barney Stinson, and can be seen on the big screen this weekend in Harold & Kumar Escape from Guantanamo Bay, reprising the heterosexualized alternate universe version of himself that he first played in Harold & Kumar Go to White Castle.
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